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Synthesis of 1,4- and 1,5-Diaryl-1H-Imidazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A simple method for the synthesis of 1,4- and 1,5-diarylimidazoles has been developed. The method is based on the condensation of appropriate α-diketone monooxime with aromatic amines and formaldehyde in the presence of boron trifluoride etherate leading to the formation of stable boron trifluoride complexes of imidazole N-oxides. Further reduction of these complexes led to the formation of corresponding imidazoles.

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Authors and Affiliations

  1. Department of Fine Organic Synthesis and Chemistry of Dyes, D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow, 125047, Russia

    V. S. Mityanov, V. P. Perevalov & I. I. Tkach

Authors
  1. V. S. Mityanov
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  2. V. P. Perevalov
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  3. I. I. Tkach
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Correspondence to V. S. Mityanov.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1669–1676, November, 2014.

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Mityanov, V.S., Perevalov, V.P. & Tkach, I.I. Synthesis of 1,4- and 1,5-Diaryl-1H-Imidazoles. Chem Heterocycl Comp 50, 1534–1540 (2015). https://doi.org/10.1007/s10593-014-1621-1

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  • DOI: https://doi.org/10.1007/s10593-014-1621-1

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