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Chemistry of Heterocyclic Compounds

, Volume 50, Issue 10, pp 1478–1486 | Cite as

Synthesis, Structure, and Antiradical Activity of New Methano[1,3]Thiazolo[2,3-d][1,3,5]Benzoxa-Diazocine Derivatives

  • I. V. KulakovEmail author
  • S. A. Talipov
  • Z. T. Shulgau
  • T. M. Seilkhanov
Article

The reaction of 2,6-methano[1, 3, 5]benzoxadiazocines, obtained in Biginelli reaction, with chloroacetic acid derivatives produced previously unknown tricyclic methano[1,3]thiazolo[2,3-d][1,3,5]benz-oxadiazocines, the structure of which was proved by 1Н NMR spectroscopy and X-ray structural analysis. The methano[1,3]thiazolo[2,3-d][1,3,5]benzoxadiazocines showed no antiradical activity in contrast to the starting 2,6-methano[1,3,5]benzoxadiazocines.

Keywords

2H-2,6-methano[1,3,5]benzoxadiazocines salicylic aldehyde thiourea Biginelli reaction intramolecular heterocyclization X-ray structural analysis 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • I. V. Kulakov
    • 1
    Email author
  • S. A. Talipov
    • 2
  • Z. T. Shulgau
    • 3
  • T. M. Seilkhanov
    • 4
  1. 1.Omsk F. M. Dostoevskii State UniversityOmskRussia
  2. 2.Institute of Bioorganic ChemistryTashkentUzbekistan
  3. 3.Center for Life Sciences, Inc.AstanaKazakhstan
  4. 4.Sh. Ualikhanov Kokshetau State UniversityKokshetauKazakhstan

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