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Chemistry of Heterocyclic Compounds

, Volume 50, Issue 10, pp 1450–1456 | Cite as

Microwave-Assisted Synthesis of Fused 3-Thiocarbamoylquinolines by Reinhoudt Reaction and their Modification by Hantzsch Reaction

  • A. Yu. Platonova
  • A. A. Poluikova
  • O. A. Trofimova
  • T. V. Glukhareva
  • Yu. Yu. MorzherinEmail author
Article

We have shown that the reaction of 2-dialkylaminobenzaldehydes with cyanothioacetamide leading to Knoevenagel condensation products and their cyclization according to tert-amino effect mechanism, may be significantly accelerated by using a microwave reactor. The synthesized tetrahydroquinolinо-3-carbothioamides reacted with α-bromoacetophenone in microwave reactor to give 3–(1,3-thiazol-2-yl)tetrahydroquinolines.

Keywords

quinolines thiazoles thioamides Hantzsch reaction Knoevenagel condensation Reinhoudt reaction tert-amino effect microwave irradiation 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • A. Yu. Platonova
    • 1
  • A. A. Poluikova
    • 1
  • O. A. Trofimova
    • 1
  • T. V. Glukhareva
    • 1
  • Yu. Yu. Morzherin
    • 1
    Email author
  1. 1.Ural Federal UniversityYekaterinburgRussia

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