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Microwave-Assisted Synthesis of Fused 3-Thiocarbamoylquinolines by Reinhoudt Reaction and their Modification by Hantzsch Reaction

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Chemistry of Heterocyclic Compounds Aims and scope

We have shown that the reaction of 2-dialkylaminobenzaldehydes with cyanothioacetamide leading to Knoevenagel condensation products and their cyclization according to tert-amino effect mechanism, may be significantly accelerated by using a microwave reactor. The synthesized tetrahydroquinolinо-3-carbothioamides reacted with α-bromoacetophenone in microwave reactor to give 3–(1,3-thiazol-2-yl)tetrahydroquinolines.

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Authors and Affiliations

  1. Ural Federal University, 19 Mira St., Yekaterinburg, 620002, Russia

    A. Yu. Platonova, A. A. Poluikova, O. A. Trofimova, T. V. Glukhareva & Yu. Yu. Morzherin

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  1. A. Yu. Platonova
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  2. A. A. Poluikova
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  3. O. A. Trofimova
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  4. T. V. Glukhareva
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  5. Yu. Yu. Morzherin
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Corresponding author

Correspondence to Yu. Yu. Morzherin.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1576-1582, October, 2014.

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Platonova, A.Y., Poluikova, A.A., Trofimova, O.A. et al. Microwave-Assisted Synthesis of Fused 3-Thiocarbamoylquinolines by Reinhoudt Reaction and their Modification by Hantzsch Reaction. Chem Heterocycl Comp 50, 1450–1456 (2015). https://doi.org/10.1007/s10593-014-1609-x

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  • DOI: https://doi.org/10.1007/s10593-014-1609-x

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