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2,1-Benzothiazine 2,2-Dioxides. 5*. Hydrolysis of Alkyl 1-R-4-Hydroxy-2,2-Dioxo-1Н-2λ6,1-Benzo-Thiazine-3-Carboxylates**

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Chemistry of Heterocyclic Compounds Aims and scope

Hydrolysis of 1-R-4-hydroxy-2,2-dioxo-1Н-2λ6,1-benzothiazine-3-carboxylate esters in HCl–AcOH–H2O mixture at 60°С was accompanied by decarboxylation and led to 1-R-4-oxo-3,4-dihydro-1H-2λ6,1-benzo-thiazine-2,2-diones. In the alkaline medium, regardless of the type of the substituent at position 1, analogous structural transformations occurred at first, but the thiazine ring was also destroyed along with the ester fragment when performing the reaction for a longer time.

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Authors and Affiliations

  1. National University of Pharmacy, 53 Pushkinskaya St., Kharkiv, 61002, Ukraine

    I. V. Ukrainets & L. A. Petrushova

  2. N. I. Pirogov Vinnitsa National Medical University, 56 Pirogov St., Vinnitsa, 21018, Ukraine

    S. P. Dzyubenko

  3. Changchun Medical College, 6177 Jilin Road, Changchun, 130031, China

    Liu Yangyang

Authors
  1. I. V. Ukrainets
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  2. L. A. Petrushova
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  3. S. P. Dzyubenko
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  4. Liu Yangyang
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Corresponding author

Correspondence to I. V. Ukrainets.

Additional information

*For Communication 4, see [1].

**Dedicated to Academician O. N. Chupakhin on the occasion of his 80th birthday.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1135-1140, July, 2014.

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Ukrainets, I.V., Petrushova, L.A., Dzyubenko, S.P. et al. 2,1-Benzothiazine 2,2-Dioxides. 5*. Hydrolysis of Alkyl 1-R-4-Hydroxy-2,2-Dioxo-1Н-2λ6,1-Benzo-Thiazine-3-Carboxylates**. Chem Heterocycl Comp 50, 1047–1052 (2014). https://doi.org/10.1007/s10593-014-1563-7

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  • DOI: https://doi.org/10.1007/s10593-014-1563-7

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