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Halogen-Containing 2-methylpyrimido[1,2-a]-benzimidazol-4(10Н)-ones

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Chemistry of Heterocyclic Compounds Aims and scope

We have synthesized a series of 3-halo-substituted pyrimidobenzimidazolones and studied the alkylation reaction of the obtained derivatives.

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References

  1. S. K. Swan, W. B. Smith, T. C. Marbury, M. Schumacher, C. Dougherty, B. A. Mico, and S. A. Villano, J. Clin. Pharmacol., 47, 209 (2007).

    Article  CAS  Google Scholar 

  2. S. Chou and G. I. Marousek, Antimicrob. Agents Chemother., 50, 3470 (2006).

    Article  CAS  Google Scholar 

  3. E. D. Jones, N. Vandegraff, G. Le, N. Choi, W. Issa, K. MacFarlane, N. Thienthong, L. J. Winfield, J. A. V. Coates, L. Lu, X. Li, X. Feng, C. Yu, D. I. Rhodes, and J. J. Deadman, Bioorg. Med. Chem. Lett., 20, 5913 (2010).

    Article  CAS  Google Scholar 

  4. T. Chiba, S. Shigeta, and Y. Numazaki, Biol. Pharm. Bull., 18, 1081 (1995).

    Article  CAS  Google Scholar 

  5. R. Wilcken, M. O. Zimmermann, A. Lange, A. C. Joerger, and F. M. Boeckler, J. Med. Chem., 56, 1363 (2013).

    Article  CAS  Google Scholar 

  6. M. Di Braccio, G. Grossi, M. G. Signorello, G. Leoncini, E. Cichero, P. Fossa, S. Alfei, and G. Damonte, Eur. J. Med. Chem., 62, 564 (2013).

    Article  Google Scholar 

  7. A. Da Settimo, G. Primofiore, F. Da Settimo, A. M. Marini, S. Taliani, S. Salerno, and L. Dalla Via, J. Heterocycl. Chem., 40, 1091 (2003).

    Article  Google Scholar 

  8. M. Witvrouw, D. Daelemans, C. Pannecouque, J. Neyts, G. Andrei, R. Snoeck, A. M. Vandamme, J. Balzarini, J. Desmyter, M. Baba, and E. De Clercq, Antivir. Chem. Chemother., 9, 403 (1998).

    CAS  Google Scholar 

  9. E. Filipponi, G. Cruciani, O. Tabarrini, V. Cecchetti, and A. Fravolini, J. Comput. Aided Mol. Des., 15, 203 (2001).

    Article  CAS  Google Scholar 

  10. I. Hermecz, Á. Horváth, L. Vasvári-Debreczy, and Z. Mészáros, Synthesis, 152 (1984).

  11. H. Ogura, M. Kawano, and T. Itoh, Chem. Pharm. Bull., 21, 2019 (1973).

    Article  CAS  Google Scholar 

  12. E. N. Ulomskiy, N. R. Medvedeva, A. V. Shchepochkin, O. S. Eltsov, V. L. Rusinov, O. N. Chupakhin, E. G. Deyeva, and O. I. Kiselev, Khim. Geterotsikl. Soedin., 1411 (2011). [Chem. Heterocycl. Compd., 47, 1164 (2011).]

    Article  CAS  Google Scholar 

  13. H. Bohme and K. H. Weisel, Arch. Pharm. (Weinheim), 309, 959 (1976).

    Article  CAS  Google Scholar 

  14. S. M. Sirko, N. Yu. Gorobets, V. I. Musatov, and S. M. Desenko, Molecules, 14, 5223 (2009).

    Article  CAS  Google Scholar 

  15. K. B. Puttaraju, K. Shivashankar, Chandra, M. Mahendra, V. P. Rasal, P. N. Venkata Vivek, K. Rai, and M. Beebina Chanu, Eur. J. Med. Chem., 69, 316 (2013).

    Article  CAS  Google Scholar 

  16. http://shelx.uni-ac.gwdg.de/SHELX/download.php.

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The work was performed with financial support from the Russian Foundation for Basic Research (grant 13-0300867 А) and within the framework of State Assignment from the Ministry of Education and Science of the Russian Federation.

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Authors and Affiliations

  1. Ural Federal University named after the First President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002, Russia

    E. N. Ulomskiy, O. S. El’tsov, S. S. Borisov, K. V. Savateev, E. K. Voinkov, V. V. Fedotov & V. L. Rusinov

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  1. E. N. Ulomskiy
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  2. O. S. El’tsov
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  3. S. S. Borisov
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  4. K. V. Savateev
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  5. E. K. Voinkov
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  6. V. V. Fedotov
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  7. V. L. Rusinov
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Corresponding author

Correspondence to E. N. Ulomskiy.

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Dedicated to Academician O. N. Chupakhin on the occasion of his 80th birthday.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1090-1099, July, 2014.

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Ulomskiy, E.N., El’tsov, O.S., Borisov, S.S. et al. Halogen-Containing 2-methylpyrimido[1,2-a]-benzimidazol-4(10Н)-ones. Chem Heterocycl Comp 50, 1005–1013 (2014). https://doi.org/10.1007/s10593-014-1556-6

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  • DOI: https://doi.org/10.1007/s10593-014-1556-6

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