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Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties

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Chemistry of Heterocyclic Compounds Aims and scope

Inspired by the concept of multicomponent reactions, a novel one-pot synthesis involving arylglyoxals, 5-aminopyrazoles, and Meldrum's acid has been developed and employed for the creation of a small library of 4-aroyl-2(1),4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones. The alkylation, acylation, reduction, and oxidation reactions of 4-aroyl-3-methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones have been studied.

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Authors and Affiliations

  1. State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, 60 Lenina Ave., Kharkiv, 61001, Ukraine

    O. N. Petrova, L. L. Zamigajlo, I. M. Gella, V. I. Musatov, S. V. Shishkina, O. V. Shishkin, E. V. Vashchenko & V. V. Lipson

  2. V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine

    I. M. Gella, O. V. Shishkin & V. V. Lipson

  3. Enamine Ltd., 23 Alexandra Matrosova St., Kyiv, 01103, Ukraine

    A. V. Borisov

  4. Antidiabetic Drug Laboratory, SI “V. Ya. Danilevsky Institute for Endocrine Pathology Problems”, 10 Artema St., Kharkiv, 61002, Ukraine

    V. V. Lipson

Authors
  1. O. N. Petrova
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  2. L. L. Zamigajlo
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  3. I. M. Gella
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  4. V. I. Musatov
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  5. S. V. Shishkina
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  6. O. V. Shishkin
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  7. E. V. Vashchenko
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  8. A. V. Borisov
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  9. V. V. Lipson
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Corresponding author

Correspondence to V. V. Lipson.

Additional information

Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 562-576, April, 2014.

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Petrova, O.N., Zamigajlo, L.L., Gella, I.M. et al. Three-Component Synthesis of 4-Aroyl-2(1),4,5,7-Tetrahydropyrazolo[3,4-b]Pyridin-6-Ones and Their Properties. Chem Heterocycl Comp 50, 514–527 (2014). https://doi.org/10.1007/s10593-014-1502-7

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  • DOI: https://doi.org/10.1007/s10593-014-1502-7

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