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Reaction of 3-Alkanoylquinoxalin-2-Ones with Ammonium Acetate in DMSO – A New Method for the Synthesis of Pyrroles

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Chemistry of Heterocyclic Compounds Aims and scope

The interaction of 3-alkanoylquinoxalin-2-ones with NH4OAc in DMSO at 105-120°С produced pyrrole derivatives according to a novel [С2+N+С2] scheme, while the –(CO)–CH2– fragment of the substituent at position 3 of the quinoxalinones served as the source of two-carbon fragments С(2)–С(3) and С(4)–С(5), and the nitrogen source was NH4OAc.

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This project received financial support from the Russian Foundation for Basic Research (grant 13-03-00123-a).

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  1. A. E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center, Russian Academy of Sciences, 8 Arbuzova St.,, Kazan, 420088, Republic of Tatarstan, Russia

    A. A. Kalinin & V. A. Mamedov

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  1. A. A. Kalinin
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Correspondence to V. A. Mamedov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 219-227, February, 2014.

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Kalinin, A.A., Mamedov, V.A. Reaction of 3-Alkanoylquinoxalin-2-Ones with Ammonium Acetate in DMSO – A New Method for the Synthesis of Pyrroles. Chem Heterocycl Comp 50, 195–203 (2014). https://doi.org/10.1007/s10593-014-1461-z

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