The peculiarities of the nitration reaction under acidic conditions were studied for a series of alkylamino-1,2,4,5-tetrazines. It was found that the extent of N,N'-dialkyl-1,2,4,5-tetrazine-3,6-diamine nitration was determined by the concentration of nitric acid and the selection of alkyl substituents at the exocyclic nitrogen atom. A new method was developed for the preparation of unsymmetrically substituted N,N'-dialkyl-1,2,4,5-tetrazine-3,6-diamines from N-nitro derivatives of N-alkyl-1,2,4,5-tetrazin-3-amines.
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This work was performed with financial support from the Ministry of Education and Science of the Russian Federation within the framework of the program "Development of the higher school scientific potential" (grant 3.5452.2011).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 59-71, 2014.
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Rudakov, G.F., Ustinova, T.V., Kozlov, I.B. et al. Synthesis and Properties of Alkylnitramino-1,2,4,5-Tetrazines. Chem Heterocycl Comp 50, 53–64 (2014). https://doi.org/10.1007/s10593-014-1448-9
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DOI: https://doi.org/10.1007/s10593-014-1448-9