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Chemistry of Heterocyclic Compounds

, Volume 49, Issue 11, pp 1681–1686 | Cite as

Alkylation of Tetrahydropyrimidine-2-thiones with Ethyl Chloroacetate

  • A. K. ShiryaevEmail author
  • N. G. Kolesnikova
  • N. M. Kuznetsova
  • E. A. Lashmanova
Article

Reaction conditions were found for the alkylation of tetrahydropyrimidine-2-thiones with ethyl chloroacetate, preventing a subsequent cyclization. Only one of the ester groups in the obtained alkylation products was subject to alkaline hydrolysis, while a treatment with ammonia in alcohol resulted in thiazolo[3,2-a]pyrimidines.

Keywords

dihydropyrimidines esters of haloacetic acids tetrahydropyrimidine-2-thiones thiazolo[3,2-a]pyrimidines alkylation hydrolysis 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • A. K. Shiryaev
    • 1
    Email author
  • N. G. Kolesnikova
    • 1
  • N. M. Kuznetsova
    • 1
  • E. A. Lashmanova
    • 1
  1. 1.Samara State Technical UniversitySamaraRussia

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