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Chemistry of Heterocyclic Compounds

, Volume 49, Issue 11, pp 1674–1680 | Cite as

The Synthesis and Cytotoxic Properties of Selenopheno[3,2-c]- and Selenopheno-[2,3-c]quinolones*

  • P. ArsenyanEmail author
  • J. Vasiljeva
  • I. Shestakova
  • I. Domracheva
  • S. Belyakov
Article

We have developed a method for the synthesis of novel selenophene-containing polycyclic heterocycles, derivatives of selenopheno[3,2-c]- and selenopheno[2,3-c]quinolones. The cytotoxic activity of these compounds was studied in vitro. The molecular structure of 3-bromo-5-methyl-2-(piperidin-2-ylmethyl)selenopheno[3,2-c]quinolin-4(5H)-one was confirmed by X-ray analysis.

Keywords

quinolone selenium selenophene cytotoxicity electrophilic addition intramolecular cyclization X-ray structural analysis 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • P. Arsenyan
    • 1
    Email author
  • J. Vasiljeva
    • 1
  • I. Shestakova
    • 1
  • I. Domracheva
    • 1
  • S. Belyakov
    • 1
  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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