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Anodic Cyclization: A Protocol for the Green Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles

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Chemistry of Heterocyclic Compounds Aims and scope

An efficient and simple one-pot synthesis of chemically and pharmaceutically interesting 2,5-di-substituted 1,3,4-oxadiazoles is reported. The protocol involves anodic oxidation of N′-aroyl-hydrazones of aromatic aldehydes using LiClO4 as supporting electrolyte in MeCN solution under controlled potential at room temperature. The products were characterized by spectroscopic methods, and the mechanism was deduced from voltammetry studies. The mild reaction conditions, short reaction time, and excellent yields are notable advantages of the developed protocol.

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We sincerely thank SAIF, Punjab University, Chandigarh, for providing microanalyses and spectra, and also CST-UP for financial support of the work.

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Authors and Affiliations

  1. University of Allahabad, Allahabad, 211002, Uttar Pradesh, India

    S. Singh, L. K. Sharma, A. Saraswat, M. K. Srivastava, I. R. Siddiqui & R. K. P. Singh

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  1. S. Singh
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  2. L. K. Sharma
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  3. A. Saraswat
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  4. M. K. Srivastava
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  5. I. R. Siddiqui
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Correspondence to R. K. P. Singh.

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Publushed in Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1626-1632, October, 2013.

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Singh, S., Sharma, L.K., Saraswat, A. et al. Anodic Cyclization: A Protocol for the Green Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles. Chem Heterocycl Comp 49, 1508–1514 (2014). https://doi.org/10.1007/s10593-014-1402-x

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  • DOI: https://doi.org/10.1007/s10593-014-1402-x

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