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Synthesis and Alkylation of Diethyl 6-Aryl-2-Oxo-1,2,3,6-Tetrahydropyrimidine-4,5-Dicarboxylates

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Chemistry of Heterocyclic Compounds Aims and scope

We have demonstrated the preparation of diethyl 6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates by reaction of urea, oxalacetic ester, and aromatic aldehydes with substituents of various electronic properties. Alkylation of the obtained compounds in the alkyl halogenide–KOH/Н2О–MeCN system resulted in mixtures of N-alkyl derivatives, which can be separated by column chromatography. Longer reaction time led selectively to 1,3-dialkylation products.

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Authors and Affiliations

  1. V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv, 61022, Ukraine

    M. A. Kolosov, M. J. K. Al-Ogaili, V. S. Parkhomenko & V. D. Orlov

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  1. M. A. Kolosov
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  2. M. J. K. Al-Ogaili
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  3. V. S. Parkhomenko
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  4. V. D. Orlov
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Correspondence to M. A. Kolosov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1599-1605, October, 2013.

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Kolosov, M.A., Al-Ogaili, M.J.K., Parkhomenko, V.S. et al. Synthesis and Alkylation of Diethyl 6-Aryl-2-Oxo-1,2,3,6-Tetrahydropyrimidine-4,5-Dicarboxylates. Chem Heterocycl Comp 49, 1484–1489 (2014). https://doi.org/10.1007/s10593-014-1399-1

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  • DOI: https://doi.org/10.1007/s10593-014-1399-1

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