A novel method for the synthesis of 1-aryl-1,2-dihydro-3H-naphtho[1,2-e][1,3]oxazin-3-one derivatives employing one-pot three-component reaction of β-naphthol, aromatic aldehydes, and urea using a catalytic amount of guanidine hydrochloride under solvent-free thermal conditions is described. This method provides several advantages like clean and environmentally benign reaction, simple work-up procedure, low cost, easy product separation without need of further purification with column chromatography, shorter reaction times, and high yields.
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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1474-1478, September, 2013.
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Olyaei, A., Sadeghpour, M. & Zarnegar, M. Guanidine Hydrochloride Catalyzed, Rapid and Efficient One-Pot Synthesis of Naphthoxazinones Under Solvent-Free Conditions. Chem Heterocycl Comp 49, 1374–1377 (2013). https://doi.org/10.1007/s10593-013-1387-x
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DOI: https://doi.org/10.1007/s10593-013-1387-x