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Formation of 3,4,5,6-tetrahydroquinazolin-2(1H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-ones with chalcones

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Chemistry of Heterocyclic Compounds Aims and scope

A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones in MeOH–KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH–MeONa with the formation of derivatives of 4,5,7-triaryl-3,4,5,6-tetrahydroquinazolin-2(1H)-one.

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Correspondence to M. A. Kolosov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1253-1258, August, 2013.

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Kolosov, M.A., Kulyk, O.G., Starchenko, O.I. et al. Formation of 3,4,5,6-tetrahydroquinazolin-2(1H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-ones with chalcones. Chem Heterocycl Comp 49, 1166–1171 (2013). https://doi.org/10.1007/s10593-013-1359-1

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  • DOI: https://doi.org/10.1007/s10593-013-1359-1

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