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Synthesis of Novel Unsymmetrically Substituted 1,4-Dihydroisonicotinic Acid and its Derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

The synthesis of new unsymmetrically substituted 1,4-dihydroisonicotinic acid bearing cyano and acetyl groups in positions 3 and 5 of the heterocycle has been developed. The methyl, ethoxycarbonylmethyl, and propionyloxymethyl esters of the acid have been obtained. The method of N-alkylation reaction of synthesized 1,4-dihydroisonicotinic acid esters has been elaborated.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia

    I. Goba, B. Turovska, S. Belyakov & E. Liepinsh

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  1. I. Goba
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  2. B. Turovska
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  3. S. Belyakov
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  4. E. Liepinsh
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Correspondence to I. Goba.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 778–787, May, 2013.

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Goba, I., Turovska, B., Belyakov, S. et al. Synthesis of Novel Unsymmetrically Substituted 1,4-Dihydroisonicotinic Acid and its Derivatives. Chem Heterocycl Comp 49, 726–735 (2013). https://doi.org/10.1007/s10593-013-1304-3

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  • DOI: https://doi.org/10.1007/s10593-013-1304-3

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