Synthetic approaches to the construction of bicyclic systems containing the imidazole nucleus have been considered. Methods for obtaining derivatives of imidazo[1,2-a]pyrazine and imidazo[1,2-a]pyrimidine have been studied, and methods have been developed for catalytic hydrogenation of these compounds. Partial reduction of the imidazole ring on imidazo[1,2-a]pyrimidine hydrogenation has been discovered for the first time.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 754-762, May, 2013.
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Borisov, A.V., Tolmachev, A.A., Zavada, O.A. et al. Synthesis of imidazo[1,2-a]pyrazine and imidazo[1,2-a]pyrimidine derivatives. Chem Heterocycl Comp 49, 704–711 (2013). https://doi.org/10.1007/s10593-013-1301-6
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DOI: https://doi.org/10.1007/s10593-013-1301-6