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Chemistry of Heterocyclic Compounds

, Volume 49, Issue 4, pp 598–603 | Cite as

Ring-chain tautomerism of 2-aryl-6-oxohexahydropyrimidine-4-carboxylic acid sodium salts

  • A. Yu. Ershov
  • D. G. Nasledov
  • K. V. Nasonova
  • K. V. Sezyavina
  • T. V. Susarova
  • I. V. Lagoda
  • V. V. Shamanin
Article

It was shown by 1H and 13C NMR spectroscopy that the 2-aryl-6-oxohexahydropyrimidine-4-carboxylic acid sodium salts existed in D2O solution as a tautomeric mixture of cyclic and linear forms. The cyclic form consisted of two (2RS,4S)-stereoisomers, differing in the aryl substituent configuration at the pyrimidine ring C-2 atom.

Keywords

2-aryl-6-oxohexahydropyrimidine-4-carboxylic acids ring-chain tautomerism 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • A. Yu. Ershov
    • 1
  • D. G. Nasledov
    • 1
  • K. V. Nasonova
    • 1
  • K. V. Sezyavina
    • 1
  • T. V. Susarova
    • 1
  • I. V. Lagoda
    • 2
  • V. V. Shamanin
    • 1
  1. 1.Institute of Macromolecular CompoundsRussian Academy of SciencesSaint PetersburgRussia
  2. 2.Research Test Medical and Biological Protection Center, State Research Test Institute of Military MedicineMinistry of Defence of the Russian FederationSaint-PetersburgRussia

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