Chemistry of Heterocyclic Compounds

, Volume 49, Issue 4, pp 591–597 | Cite as

Investigation of the Chlorination of 4-(Perfluoroalkyl)-5-(p-toluenesulfonyl)uracils. Synthesis of 5-Chloro-6-(perfluoroalkyl)-5-(p-toluenesulfonyl)pyrimidine-2,4(3H,5H)-diones

  • A. P. Gudz
  • A. S. Kanishchev
  • Yu. G. Vlasenko
  • A. N. Chernega
  • Yu. G. Shermolovich

Chlorination of 4-(perfluoroalkyl)-5-(p-toluenesulfonyl)-2,6-bis(trimethylsilyloxy)pyrimidines led to the formation of 5-chloro-6-(perfluoroalkyl)-5-(p-toluenesulfonyl)pyrimidine-2,4(3H,5H)-diones, the structure of which was confirmed by NMR spectroscopy and X-ray structural analysis. The reactions of chlorinated pyrimidine-2,4(3H,5H)-diones with nucleophiles were investigated.


chlorohydrin pyrimidinone uracil chlorination silylation 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • A. P. Gudz
    • 1
  • A. S. Kanishchev
    • 1
  • Yu. G. Vlasenko
    • 1
  • A. N. Chernega
    • 1
  • Yu. G. Shermolovich
    • 1
  1. 1.Institute of Organic ChemistryNational Academy of Sciences of UkraineKyivUkraine

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