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One-pot synthesis of aryl(hetaryl)-thiazolylphthalazine-1,4-diones via a multicomponent approach

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Chemistry of Heterocyclic Compounds Aims and scope

An expeditious one-pot synthesis has been developed to obtain aryl(hetaryl)-substituted thiazolylphthalazine-1,4-diones via a multicomponent approach. The reaction of phenacyl bromides with thiosemicarbazide and phthalic anhydride afforded arylthiazolylphthalazine-1,4-diones. The reaction of 3-(2-bromoacetyl)coumarins with thiosemicarbazide and phthalic anhydride afforded hetaryl-containing 2-thiazolylphthalazine-1,4-diones under the same reaction conditions in excellent yields. The structures of all the synthesized compounds were confirmed by their analytical and spectral data.

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Authors and Affiliations

  1. National Institute of Technology, Warangal-, 506 004, A. P., India

    V. S. R. Chunduru & R. R. Vedula

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  1. V. S. R. Chunduru
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  2. R. R. Vedula
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Correspondence to R. R. Vedula.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 628–632, April, 2013.

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Chunduru, V.S.R., Vedula, R.R. One-pot synthesis of aryl(hetaryl)-thiazolylphthalazine-1,4-diones via a multicomponent approach. Chem Heterocycl Comp 49, 586–590 (2013). https://doi.org/10.1007/s10593-013-1285-2

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  • DOI: https://doi.org/10.1007/s10593-013-1285-2

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