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Chemistry of Heterocyclic Compounds

, Volume 49, Issue 3, pp 404–407 | Cite as

Improved method for the synthesis of 1-vinylindole

  • E. Yu. Shmidt
  • N. I. Protsuk
  • A. M. Vasil’tsov
  • A. V. Ivanov
  • A. I. Mikhaleva
  • B. A. Trofimov
Article

A highly efficient method has been developed for the synthesis of 1-vinylindole based on the vinylation of indole by acetylene at atmospheric pressure using the superbase KOH–DMSO catalytic system. The method allows the preparation of the 1-vinylindole in 94% yield with a purity of 99% (after a single distillation of the crude product).

Keywords

acetylene indole 1-vinylindole superbase vinylation 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • E. Yu. Shmidt
    • 1
  • N. I. Protsuk
    • 1
  • A. M. Vasil’tsov
    • 1
  • A. V. Ivanov
    • 1
  • A. I. Mikhaleva
    • 1
  • B. A. Trofimov
    • 1
  1. 1.A. E. Favorsky Institute of ChemistrySiberian Branch of the Russian Academy of SciencesIrkutskRussia

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