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Synthesis of 7-alkyl-4-amino-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acids

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Chemistry of Heterocyclic Compounds Aims and scope

Two variants are discussed for the synthesis of ethyl N-alkyl-N-(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimido- [5',4':4,5]pyrrolo[2,1-c][1,4]oxazines containing 3-chloropropyl groups at position 8 have been prepared.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv, 02660, Ukraine

    E. V. Verves, A. V. Kucher, L. V. Muzychka & O. B. Smolii

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  1. E. V. Verves
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  2. A. V. Kucher
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  3. L. V. Muzychka
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  4. O. B. Smolii
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Correspondence to O. B. Smolii.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, 1968-1976. December, 2013.

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Verves, E.V., Kucher, A.V., Muzychka, L.V. et al. Synthesis of 7-alkyl-4-amino-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acids. Chem Heterocycl Comp 48, 1844–1852 (2013). https://doi.org/10.1007/s10593-013-1218-0

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