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Synthesis of 2-unsubstituted 1-arylimidazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A method has been developed for the synthesis of 1-arylimidazoles lacking a substituent at position 2, featuring the preparation of 1-arylimidazole N-oxides stabilized as boron trifluoride derivatives, with subsequent reduction to the desired imidazoles. This method permits broad variation of the substituents in the aryl part of these molecules.

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Authors and Affiliations

  1. D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow, 125047, Russia

    V. S. Mityanov, V. P. Perevalov & I. I. Tkach

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  1. V. S. Mityanov
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  2. V. P. Perevalov
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  3. I. I. Tkach
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Correspondence to V. S. Mityanov.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1916-1923, December, 2012.

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Mityanov, V.S., Perevalov, V.P. & Tkach, I.I. Synthesis of 2-unsubstituted 1-arylimidazoles. Chem Heterocycl Comp 48, 1793–1800 (2013). https://doi.org/10.1007/s10593-013-1210-8

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  • DOI: https://doi.org/10.1007/s10593-013-1210-8

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