The reaction of 2-substituted 7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids with hydrazine was studied. This reaction gave 5-substituted 8,8-dimethyl-3,7,8,9-tetrahydro-2H-pyrido-[4,3,2-de]cinnolin-3-ones in good yields. A possible reaction mechanism was discussed using nonempirical quantum-chemical calculations.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1634-1638, October, 2012.
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Rudenko, D.A., Shurov, S.N., Vakhrin, M.I. et al. Reaction of 2-substituted 7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids with hydrazine. Synthesis of 5-substituted 8,8-dimethyl-3,7,8,9-tetrahydro-2H-pyrido-[4,3,2-de]cinnolin-3-ones. Chem Heterocycl Comp 48, 1522–1526 (2013). https://doi.org/10.1007/s10593-013-1167-7
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DOI: https://doi.org/10.1007/s10593-013-1167-7