The Mannich aminomethylation of 5',6',7,'8'-tetrahydro-1'H,3'H-spiro[cyclohexane-1,2'-quinazolin]-4'-one leads to formation of a heterocyclic system containing an annelated azabicyclic fragment. Hydrolysis of the indicated spirans gives 3-azabicyclo[3.3.1]nonanes.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 995-1000, June, 2012.
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Markov, V.I., Farat, O.K. 5',6',7',8'-Tetrahydro-1'H,3'H-spiro[cyclohexane-1,2'-quinazolin]-4'-one in Mannich reaction. Chem Heterocycl Comp 48, 925–930 (2012). https://doi.org/10.1007/s10593-012-1078-z
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DOI: https://doi.org/10.1007/s10593-012-1078-z