The interaction of the ethyl ester or pyrrolidide of 3,3-diaminoacrylic acid with aromatic and heteroaromatic nitriles containing a labile halogen atom in the ortho position, leads to the formation of products of its substitution by the α-carbon atom of the diaminoacrylic acid derivative. The compounds obtained are cyclized smoothly into fused diaminoazines.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 465-470, March, 2012.
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Igumnova, E.M., Selivanov, S.I., Dar’in, D.V. et al. Reactions of 3,3-diaminoacrylic acid derivatives with o-haloarenecarbonitriles. Synthesis of fused azines. Chem Heterocycl Comp 48, 436–441 (2012). https://doi.org/10.1007/s10593-012-1011-5
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DOI: https://doi.org/10.1007/s10593-012-1011-5