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Chemistry of Heterocyclic Compounds

, Volume 48, Issue 2, pp 372–376 | Cite as

Regiodirected synthesis of polyfluoro-alkylated pyrimido[1,2-a]benzimidazoles

  • M. V. Goryaeva
  • Ya. V. Burgart
  • V. I. SaloutinEmail author
  • O. N. Chupakhin
Article

Conditions have been found for the regiodirected cyclization of 2-aminobenzimidazoles using ethyl 3-oxo-3-polyfluoroalkyl-2-ethoxymethylidenepropionates at the ethoxymethylidenefluoroacyl fragment to give ethyl pyrimidobenzimidazole-3-carboxylates.

Keywords

2-aminobenzimidazole 2-ethoxymethylidene-3-oxo-3-polyfluoroalkylpropionate pyrimido-[1,2-a]benzimidazole condensation regiodirection 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • M. V. Goryaeva
    • 1
  • Ya. V. Burgart
    • 1
  • V. I. Saloutin
    • 1
    Email author
  • O. N. Chupakhin
    • 1
  1. 1.I. Ya. Postovsky Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesYekaterinburgRussia

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