Chemistry of Heterocyclic Compounds

, Volume 48, Issue 2, pp 368–371 | Cite as

Ethyl 5-amino-3-oxo-1,2-dihydro-1H-pyrazole-1-carboxylate in the selective synthesis of partially hydrogenated pyrazolo[3,4-b]pyridin-3-ones

  • P. S. LebedˈEmail author
  • N. G. Mozgovaya
  • P. O. Kos
  • M. V. Vovk

Ethyl 5-amino-3-oxo-1,2-dihydro-1H-pyrazole-1-carboxylate undergoes selective cyclocondensation with 1,3-dicarbonyl compounds or their synthetic equivalents to give ethyl 3-oxo-1,2-dihydro-pyrazolo[3,4-b]pyridine-1-carboxylates which are readily converted to their 1-unsubstituted analogs.


5-amino-1-ethoxycarbonyl-1,2-dihydro-1H-pyrazol-3-one 5-aminopyrazol-3-one 1,3-di-carbonyl compounds pyrazolo[3,4-b]pyridin-3-ones cyclocondensation 


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • P. S. Lebedˈ
    • 1
    Email author
  • N. G. Mozgovaya
    • 1
  • P. O. Kos
    • 1
  • M. V. Vovk
    • 1
  1. 1.Institute of Organic ChemistryUkraine National Academy of SciencesKyivUkraine

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