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Synthesis of 5-(4-aminophenyl)-2-(arylamino)-1,3,4-thiadiazoles and their schiff base derivatives as antimycobacterial agents

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Chemistry of Heterocyclic Compounds Aims and scope

The condensation reaction of 5-(4-aminophenyl)-N-aryl-1,3,4-thiadiazol-2-ylamines with salicyl-aldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 5-bromosalicylaldehyde, 5-chlorosalicyl-aldehyde, 4-methoxybenzaldehyde, 3-nitrobenzaldehyde, and 4-nitrobenzaldehyde results in series of new Schiff bases. The synthesized compounds were tested for their antimicrobial efficiency against Mycobacterium smegmatis PTCC 1307 in vitro. All compounds showed significant antiproliferative activity against M. smegmatis.

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Authors and Affiliations

  1. Urmia University, Urmia, 57159, Iran

    K. A. Dilmaghani, F. Nasuhi Pur, N. Shokoufeh & F. Ghadiri

  2. Urmia Medical Science University, Urmia, 57159, Iran

    N. H. Jazani

  3. Institute of Standard and Industrial Research of Iran, Urmia, 57159, Iran

    F. M. Fakhraee

Authors
  1. K. A. Dilmaghani
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  2. N. H. Jazani
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  3. F. Nasuhi Pur
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  4. N. Shokoufeh
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  5. F. Ghadiri
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  6. F. M. Fakhraee
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Correspondence to K. A. Dilmaghani.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 384-389, February, 2012.

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Dilmaghani, K.A., Jazani, N.H., Pur, F.N. et al. Synthesis of 5-(4-aminophenyl)-2-(arylamino)-1,3,4-thiadiazoles and their schiff base derivatives as antimycobacterial agents. Chem Heterocycl Comp 48, 362–367 (2012). https://doi.org/10.1007/s10593-012-0998-y

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  • DOI: https://doi.org/10.1007/s10593-012-0998-y

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