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Chemistry of Heterocyclic Compounds

, Volume 48, Issue 2, pp 362–367 | Cite as

Synthesis of 5-(4-aminophenyl)-2-(arylamino)-1,3,4-thiadiazoles and their schiff base derivatives as antimycobacterial agents

  • K. A. DilmaghaniEmail author
  • N. H. Jazani
  • F. Nasuhi Pur
  • N. Shokoufeh
  • F. Ghadiri
  • F. M. Fakhraee
Article

The condensation reaction of 5-(4-aminophenyl)-N-aryl-1,3,4-thiadiazol-2-ylamines with salicyl-aldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 5-bromosalicylaldehyde, 5-chlorosalicyl-aldehyde, 4-methoxybenzaldehyde, 3-nitrobenzaldehyde, and 4-nitrobenzaldehyde results in series of new Schiff bases. The synthesized compounds were tested for their antimicrobial efficiency against Mycobacterium smegmatis PTCC 1307 in vitro. All compounds showed significant antiproliferative activity against M. smegmatis.

Keywords

salicylaldehyde 1,3,4-thiadiazole in vitro Mycobacterium smegmatis Schiff base 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • K. A. Dilmaghani
    • 1
    Email author
  • N. H. Jazani
    • 2
  • F. Nasuhi Pur
    • 1
  • N. Shokoufeh
    • 1
  • F. Ghadiri
    • 1
  • F. M. Fakhraee
    • 3
  1. 1.Urmia UniversityUrmiaIran
  2. 2.Urmia Medical Science UniversityUrmiaIran
  3. 3.Institute of Standard and Industrial Research of IranUrmiaIran

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