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Chemistry of Heterocyclic Compounds

, Volume 48, Issue 2, pp 296–300 | Cite as

Synthesis and cytotoxicity of pyridine and quinoline oxorhenium(V) complexes with tridentate (NS2, S3)/monodentate (s) coordination*

  • I. SegalEmail author
  • A. Zablotskaya
  • T. Kniess
  • I. Shestakova
Article

New oxorhenium complexes with tridentate 3-thia- and 3-methylazapentane-1,5-dithiolate and monodentate pyridine and quinoline derivatives have been synthesized. As a result of investigation of biological activity a high cytotoxicity was found for the synthesized complexes in relation to tumor cells. The specificity of the 2-pyridylthiolato[3-(N-methyl)azapentane-1,5-dithiolato]oxorhenium(V) cytotoxic action towards cells of mouse hepatoma MG-22A on a background of low acute toxicity was established.

Keywords

oxorhenium(V) complexes pyridine quinoline rhenium cytotoxicity 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • I. Segal
    • 1
    Email author
  • A. Zablotskaya
    • 1
  • T. Kniess
    • 2
  • I. Shestakova
    • 1
  1. 1.Latvian Institute of Organic SynthesisRigaLatvia
  2. 2.Forschungszentrum Dresden-RossendorfDresdenGermany

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