Chemistry of Heterocyclic Compounds

, Volume 47, Issue 12, pp 1601–1602 | Cite as

Synthesis of 7,9,10,11-tetrahydro-8H-chromeno[3,2-h]quinolin-8-ones

  • V. A. OsyaninEmail author
  • D. V. Osipov
  • Yu. N. Klimochkin

Condensed pyrano[3,2-h]quinolines possess a broad spectrum of pharmacological action. Amongst them there are found compounds which are efficient for treatment of the immune system diseases [1,2] and which possess anticancer [3] and antiallergy activity [4].

We have shown that the reaction of the Mannich base 1 with the enamines 2a,b in refluxing DMF gives the 7,9,10,11-tetrahydro-8 H-chromeno[3,2- h]quinolin-8-ones 3a,b.


enamines o-quinone methides 7,9,10,11-tetrahydro-8H-chromeno[3,2-h]quinolin-8-ones Mannich bases 


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • V. A. Osyanin
    • 1
    Email author
  • D. V. Osipov
    • 1
  • Yu. N. Klimochkin
    • 1
  1. 1.Samara State Technical UniversitySamaraRussia

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