Chemistry of Heterocyclic Compounds

, Volume 47, Issue 12, pp 1561–1564 | Cite as

Synthesis of 6-sulfamoylsaccharin and study of its reactivity in alkylation reactions

  • E. M. Ivanova
  • E. Yu. Simin
  • I. V. Vozny
  • P. Trapencieris
  • R. Žalubovskis

An improved method for the preparation of 6-sulfamoylsaccharin (3-oxo-2,3-dihydro-1,2-benzo-thiazole-6-sulfonamide 1,1-dioxide) has been developed and studies of its possible direct alkylation have been carried out. It was shown that alkylation occurs regioselectively at the isothiazoline ring nitrogen atom.


6-sulfamoylsaccharin alkylation benzylation oxidative cyclization regioselectivity 


This work was carried out with the financial support of the European Social Fund (No. 2009/0203/1DP/


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • E. M. Ivanova
    • 1
  • E. Yu. Simin
    • 1
  • I. V. Vozny
    • 1
  • P. Trapencieris
    • 1
  • R. Žalubovskis
    • 1
  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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