Synthesis of 6-sulfamoylsaccharin and study of its reactivity in alkylation reactions
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An improved method for the preparation of 6-sulfamoylsaccharin (3-oxo-2,3-dihydro-1,2-benzo-thiazole-6-sulfonamide 1,1-dioxide) has been developed and studies of its possible direct alkylation have been carried out. It was shown that alkylation occurs regioselectively at the isothiazoline ring nitrogen atom.
Keywords6-sulfamoylsaccharin alkylation benzylation oxidative cyclization regioselectivity
This work was carried out with the financial support of the European Social Fund (No. 2009/0203/1DP/126.96.36.199.0/APIA/VIAA/023).
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