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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 12, pp 1502–1508 | Cite as

Synthesis and antitumor activity of 3-[(methyl)bis(5-trialkylsilyl-furan-2-yl)silyl]propylamines

  • L. IgnatovichEmail author
  • V. Romanov
  • J. Spura
  • J. Popelis
  • I. Domracheva
  • I. Shestakova
Article

Novel 3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of the Speier's catalyst. The effects of the structure of the amine and the alkyl substituent at the silicon atom on the cytotoxicity of the compounds have been studied.

Keywords

3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines cytotoxicity hydrosilylation 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • L. Ignatovich
    • 1
    Email author
  • V. Romanov
    • 1
  • J. Spura
    • 1
  • J. Popelis
    • 1
  • I. Domracheva
    • 1
  • I. Shestakova
    • 1
  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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