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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 11, pp 1460–1462 | Cite as

Synthesis of 9,11-diamino-12H-benzo[5,6]-chromeno[2,3-b]pyridine-10-carbonitriles

  • V. A. OsyaninEmail author
  • D. V. Osipov
  • Yu. N. Klimochkin
Article

The considerable interest in benzopyrano[2,3-b]pyridines is connected with the occurrence among them of compounds possessing antihistamine [1], anticaner [2], antibacterial [3], hypotensive [4], antiasthmatic [5], and other classes of activity [6, 7]. As a result a considerable attention is paid in the recent time to development of new methods to obtain substances of this class [7, 8, 9, 10].

We have shown that the reaction of the Mannich bases 1a,b with 2 equivalents of malononitrile in DMF at 120°C led to the formation of 12 H-benzo[5,6]chromeno[2,3- b]pyridines 2a,b with yields of 83 and 68%, respectively.

Keywords

9,11-diamino-12H-benzo[5,6]chromeno[2,3-b]pyridine-10-carbonitriles o-quinone methides Mannich bases 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • V. A. Osyanin
    • 1
    Email author
  • D. V. Osipov
    • 1
  • Yu. N. Klimochkin
    • 1
  1. 1.Samara State Technological UniversitySamaraRussia

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