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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 11, pp 1405–1414 | Cite as

Studies of benzoxazines 16*. Synthesis and reactivity of 2,4-substituted 4H-3,1-benzoxazines

  • E. V. GromachevskayaEmail author
  • V. G. Kul’nevich
  • T. P. Kosulina
Article

A novel method has been developed for preparation of substituted 4H-3,1-benzoxazines via formation of tetrafluoroborates. The substitution of halogen in 2-(α-haloalkyl)-4,4-diphenyl-4H-3,1-benzoxazines by NH and SH nucleophiles was performed. The effect of electrophilic substitution in the annelated aromatic ring in a series of 2,4-substituted 4H-3,1-benzoxazines has been studied.

Keywords

2-aminopyridines 4H-3,1-benzoxazines mass spectroscopic fragmentation nucleophilic and electrophilic substitution synthesis 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • E. V. Gromachevskaya
    • 1
    Email author
  • V. G. Kul’nevich
    • 1
  • T. P. Kosulina
    • 1
  1. 1.Research Institute of Heterocyclic Compounds ChemistryKuban State Technological UniversityKrasnodarRussia

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