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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 11, pp 1395–1404 | Cite as

Synthesis and properties of pyrazole carbaldehyde bis(2-hydroxyethyl)-dithioacetal hydrochlorides*

  • L. K. PapernayaEmail author
  • A. A. Shatrova
  • A. I. Albanov
  • E. V. Rudyakova
  • G. G. Levkovskaya
Article

A simple method has been developed for the synthesis of water-soluble pyrazole derivatives, namely 4-[bis(2-hydroxyethylsulfanyl)methyl]pyrazoles hydrochlorides, by the reaction of a series of pyrazole carbaldehydes with 2-mercaptoethanol in the presence of trimethylchlorosilane. When treated with aqueous ammonia solution the pyrazole-4-carbaldehydes bis(2-hydroxyethyl)dithioacetal hydro-chlorides are converted to the 4-[bis(2-hydroxyethylsulfanyl)methyl]pyrazole free bases.

Keywords

bis(2-hydroxyethyl)dithioacetals 2-mercaptoethanol 1,3-oxathiolane pyrazole carbaldehydes trimethylchlorosilane acetalization 

Notes

This work was carried out with the financial support of the Russian Foundation for Fundamental Investigations (grant 10-03-00256a).

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • L. K. Papernaya
    • 1
    Email author
  • A. A. Shatrova
    • 1
  • A. I. Albanov
    • 1
  • E. V. Rudyakova
    • 1
  • G. G. Levkovskaya
    • 1
  1. 1.A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of SciencesIrkutskRussia

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