Chemistry of Heterocyclic Compounds

, Volume 47, Issue 11, pp 1367–1371 | Cite as

2-Phenylpyrrole: one-pot selective synthesis from acetophenone oxime and acetylene by a Trofimov reaction*

  • A. I. MikhalevaEmail author
  • O. V. Petrova
  • L. N. Sobenina

We have developed a technologically orientated, one-pot way of synthesis of high purity 2-phenylpyrrole in 74% yield by treatment of acetophenone oxime with acetylene in the KOH–DMSO system. The reaction is carried out at 135-150°C under an acetylene atmospheric pressure. The synthesis was performed in laboratory (glass apparatus) and in a large scale (10 l reaction vessel).


acetylene acetophenone oxime 2-phenylpyrrole 


This work was carried out with the financial support of the Russian Foundation for Fundamental Investigations (grants 08-03-12008-ofi, 10-03-91154-GFEN_a) and the Grants Council of the President of the Russian Federation (grant NSh 3230.2010.3).


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • A. I. Mikhaleva
    • 1
    Email author
  • O. V. Petrova
    • 1
  • L. N. Sobenina
    • 1
  1. 1.A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of SciencesIrkutskRussia

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