Methods are proposed for the preparation of fluorophosphorus-containing pyrimidines through three- component reactions of dialkyl (3,3,3-trifluoro-2-oxopropyl)phosphonates. Cyclocondensation of these phosphonates with urea and aryl aldehydes gave 6-aryl-4-hydroxy-2-oxo-4-trifluoromethylhexa-hydropyrimidin-5-ylphosphonates and reaction with urea and trialkyl orthoformates led to 4-alkoxy-2-oxo-4-trifluoromethyl-1,2,3,4-tetrahydropyrimidin-5-ylphosphonates.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1191–1197, August, 2011.
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Timoshenko, V.M., Markitanov, Y.N. & Shermolovich, Y.G. Preparation of pyrimidine derivatives through three-component reactions of dialkyl (2-oxo-3,3,3-trifluoropropyl)phosphonates. Chem Heterocycl Comp 47, 977–982 (2011). https://doi.org/10.1007/s10593-011-0863-4
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DOI: https://doi.org/10.1007/s10593-011-0863-4