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Reaction of methyl 3-[(dimethylamino)methylidene]-6-fluoro-4-oxo −3,4-dihydrochroman-2-carboxylate with primary and secondary amines*

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Chemistry of Heterocyclic Compounds Aims and scope

A method was developed for substitution of the dimethylamino group by bioisosteric fragments by the action of various primary and secondary amines on methyl 3-[(dimethylamino)methylidene]-6-fluoro-4-oxo-3,4-dihydrochroman-2-carboxylate.

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References

  1. Ø. M. Andersen and К. R. Markham, Flavonoids: Chemistry, Biochemistry, and Applications, CRC, Taylor & Francis, Boca Raton, FL, 2006.

    Google Scholar 

  2. A. R. Katritzky (editor), Comprehensive Heterocyclic Chemistry III, Vol. 6. Six-membered Rings with One Heteroatom, Ch. 7–9, Elsevier, 2008.

  3. L. Mosti, P. Schenone, and G. Menozzi, J. Heterocycl. Chem., 17, 61 (1980).

    Article  CAS  Google Scholar 

  4. P. F. Schuda, C. B. Ebner, and T. M. Morgan, Tetrahedron Lett, 27, 2567 (1986).

    Article  CAS  Google Scholar 

  5. A. H. Bedair, Y. A. Ammar, A. M. El-Agrody, and Y. A. Mohamed, Proc. Indian Natl. Sci. Acad., Part B, 53, 308 (1987).

    Google Scholar 

  6. M.-C. Bellassoued-Fargeau, B. Graffe, M.-C. Sacquet, and P. Maitte, J. Heterocycl. Chem., 22, 713 (1985).

    Article  CAS  Google Scholar 

  7. H. An, S.-J. Eum, M. Koh, S. K. Lee, and S. B. Park, J. Org. Chem., 73, 1752 (2008).

    Article  CAS  Google Scholar 

  8. Ch. Wu, H. Zeng, L. Liu, D. Wang, and Y. Chen, Tetrahedron, 67, 1231 (2011).

    Article  CAS  Google Scholar 

  9. F. D. King (editor), Medicinal Chemistry: Principles and Practice, Royal Society of Chemistry, Cambridge, 2002.

    Google Scholar 

  10. E. Ziegler, G Henning, and A. K. Muller, Liebigs Ann. Chem., 1552 (1973).

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Authors and Affiliations

  1. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., Kyiv, 01601, Ukraine

    A. I. Kysil, V. S. Moskvina, A. V. Turov, Z. V. Voitenko & V. P. Khilya

Authors
  1. A. I. Kysil
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  2. V. S. Moskvina
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  3. A. V. Turov
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  4. Z. V. Voitenko
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  5. V. P. Khilya
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Corresponding author

Correspondence to V. S. Moskvina.

Additional information

*Dedicated to the happy memory of M. O. Lozinskii.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1154–1161, August, 2011.

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Kysil, A.I., Moskvina, V.S., Turov, A.V. et al. Reaction of methyl 3-[(dimethylamino)methylidene]-6-fluoro-4-oxo −3,4-dihydrochroman-2-carboxylate with primary and secondary amines*. Chem Heterocycl Comp 47, 946–952 (2011). https://doi.org/10.1007/s10593-011-0859-0

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  • DOI: https://doi.org/10.1007/s10593-011-0859-0

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