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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 7, pp 856–864 | Cite as

Synthesis of novel 1,3,4-oxadiazole derivatives and their nucleoside analogs with antioxidant and antitumor activities

  • A. A. Fadda
  • A. A.-H. Abdel-RahmanEmail author
  • W. A. El-Sayed
  • T. A. Zidan
  • F. A. Badria
Article

A series of new (1,3,4-oxadiazol-2-yl)-1H-benzo[h]quinolin-4-one derivatives were synthesized, including glucose and xylose hydrazones that were obtained by the reaction of hydrazides with monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded substituted oxadiazoline derivatives. The newly synthesized compounds were evaluated for their antioxidant properties and cytotoxicity, and showed moderate to high activities.

Keywords

acyclic nucleosides 1,3,4-oxadiazoles sugar hydrazones antioxidant activity cytotoxicity 

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • A. A. Fadda
    • 1
  • A. A.-H. Abdel-Rahman
    • 2
    Email author
  • W. A. El-Sayed
    • 3
  • T. A. Zidan
    • 1
  • F. A. Badria
    • 4
  1. 1.Department of Chemistry, Faculty of ScienceMansoura UniversityMansouraEgypt
  2. 2.Department of Chemistry, Faculty of ScienceMenoufia UniversityShebin El-KoamEgypt
  3. 3.Department of Photochemistry, National Research CenterEl-Dokki, CairoEgypt
  4. 4.Department of Drugs, Faculty of PharmacologyMansoura UniversityMansouraEgypt

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