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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 7, pp 833–837 | Cite as

4-hydroxy-2- quinolones 199*. use of N,N'-dicyclohexylcarbodiimide in the synthesis of ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylates

  • I. V. UkrainetsEmail author
  • N. Yu. Golik
  • O. V. Bevz
  • O. V. Gorokhova
Article

A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids esters based on the use of monoethyl malonate as an acylating agent in the presence of N,N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are given for the removal of specific admixtures.

Keywords

4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids acylation Dieckmann condensation 

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. V. Ukrainets
    • 1
    Email author
  • N. Yu. Golik
    • 1
  • O. V. Bevz
    • 1
  • O. V. Gorokhova
    • 1
  1. 1.National University of PharmacyKharkivUkraine

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