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Synthesis of 2-quinolinecarboxamide derivatives as potential HDAC inhibitors

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Chemistry of Heterocyclic Compounds Aims and scope

Inhibition of histone deacetylase activity appears as an original and effective approach for the treatment of cancer. A series of novel quinoline-containing derivatives has been synthesized and found that some of these compounds possess nanomolar histone deacetylase inhibitory activity.

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This work was supported by the European Social Fund (No. 2009/0203/1DP/1.1.1.2.0/09/APIA/VIAA/023).

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga, LV-1006, Latvia

    O. Habarova, O. Bobiļeva, E. Loža & N. Romančikova

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  1. O. Habarova
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  2. O. Bobiļeva
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  3. E. Loža
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  4. N. Romančikova
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Correspondence to O. Habarova.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 871–880, June, 2011.

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Habarova, O., Bobiļeva, O., Loža, E. et al. Synthesis of 2-quinolinecarboxamide derivatives as potential HDAC inhibitors. Chem Heterocycl Comp 47, 719–727 (2011). https://doi.org/10.1007/s10593-011-0825-x

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  • DOI: https://doi.org/10.1007/s10593-011-0825-x

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