The reaction of 5-(het)aryl-1-ethyl-2(1H)-pyrazinones with terminal arylacetylenes, leading to a mixture of two isomeric 4-aryl- and 5-aryl-substituted 2(1H)-pyridones has been investigated. The regioselectivity of this reaction has been shown on the basis of reaction mixtures study by chromato-mass spectrometry. A crystallographic investigation of the synthesized 2(1H)-pyridones and also a forecast of their potential biological activity have been carried out.
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The work was carried out with the financial support for Programs of the Ural Branch Russian Academy of Sciences 09-I-3-2004, 09-P-3-1015, 09-T-3-1022, Goscontract No. 02.740.11.0260, and also grants from the Russian Fund for Fundamental Investigations (RFFI) 10-03-96078-r_ural_a and VNSh-65261.2010.3.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 860–870, June, 2011.
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Verbitskiy, E.V., Cheprakova, E.M., Slepuhin, P.A. et al. Reactions of 5-(het)aryl-1-ethyl-2(1H )-pyrazinones with terminal arylacetylenes promoted by microwave radiation. Chem Heterocycl Comp 47, 710–718 (2011). https://doi.org/10.1007/s10593-011-0824-y
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DOI: https://doi.org/10.1007/s10593-011-0824-y