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Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6- carboxylates as a new class of antibacterial and antifungal agents

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Chemistry of Heterocyclic Compounds Aims and scope

A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6-carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex-3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.

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Authors and Affiliations

  1. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalai, Nagar-608 002, Tamil Nadu, India

    J. Thanusu, V. Kanagarajan & M. Gopalakrishnan

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  1. J. Thanusu
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  2. V. Kanagarajan
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  3. M. Gopalakrishnan
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Correspondence to M. Gopalakrishnan.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 696–705, May, 2011.

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Thanusu, J., Kanagarajan, V. & Gopalakrishnan, M. Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6- carboxylates as a new class of antibacterial and antifungal agents. Chem Heterocycl Comp 47, 575–583 (2011). https://doi.org/10.1007/s10593-011-0801-5

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  • DOI: https://doi.org/10.1007/s10593-011-0801-5

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