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Chemistry of Heterocyclic Compounds

, Volume 47, Issue 2, pp 182–193 | Cite as

Preparation of chiral pyrrole derivatives by the Paal-Knorr reaction

  • I. O. Ryzhkov
  • I. A. Andreev
  • G. M. Belov
  • A. V. KurkinEmail author
  • M. A. Yurovskaya
Article

A new approach has been developed for the synthesis of N-alkylpyrroles with a chiral substituent at the nitrogen atom by the Paal-Knorr reaction using esters of amino acids as the source of chirality.

Keywords

1,4-dicarbonyl compounds 2,5-dimethyl- and 5-aryl-2-methylpyrroles with a chiral substituent at the nitrogen atom chiral pyrrole derivatives iodine-catalyzed cyclization Paal-Knorr method Stetter reaction 

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. O. Ryzhkov
    • 1
  • I. A. Andreev
    • 1
  • G. M. Belov
    • 1
  • A. V. Kurkin
    • 1
    Email author
  • M. A. Yurovskaya
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscowRussia

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