Chemistry of Heterocyclic Compounds

, Volume 47, Issue 1, pp 101–107 | Cite as

Synthesis and pharmacological activities of some dibenzopyrazolocinnolines and dibenzopyridazinoquinoxalines

  • A. M. AmerEmail author
  • A. F. El-Farargy
  • N. M. Yousif
  • A. A. Fayed

Derivatives of three new classes of heterocyclic compounds have been synthesized. The first class comprises the synthesis of pyrimidino- and imidazolopyrazolopyridazine using 11 H-dibenzo[f,h]pyrazolo[3,4-c]-cinnoline-13-amine. The second class involves the synthesis of triazine derivatives using 11 H-dibenzo-[f,h]pyrazolo[3,4-c]cinnoline-13-diazonium chloride. The third class deals with the synthesis of polycyclic compounds using dibenzo[f,h]pyridazino[4,5-b]quinoxaline-10,13-diamine. The pharmacological screening has shown that several of these compounds have good antiparkinsonian activities comparable to Benzatropine. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.


pyridazine pyrimidine triazine antiparkinsonian activity 


  1. 1.
    J. Clark, M. S. Shahhet, D. Korakas, and G. J. Varvounis, J. Heterocycl. Chem., 30, 1065 (1993).CrossRefGoogle Scholar
  2. 2.
    K. Ogawa, I. Yamawaki, Y.-I. Matsusita, N. Nomura, P. F. Kador, and J. H. Kinoshita, Eur. J. Med. Chem., 28, 769 (1993).CrossRefGoogle Scholar
  3. 3.
    B. Tozkoparan, M. Ertan, P. Kelicen, and R. Demirdamar, Farmaco, 54, 588 (1999).CrossRefGoogle Scholar
  4. 4.
    J. Quiroga, B. Insuasty, S. Cruz, P. Hernandez, A. Bolanos, R. Moreno, A. Hormaza, and R. H. S. de Almeida, J. Heterocycl. Chem., 35, 333 (1998).CrossRefGoogle Scholar
  5. 5.
    M. Santagati, M. Modica, A. Santagati, F. Russo, and S. Spampinato, Pharmazie, 51, 7 (1996).Google Scholar
  6. 6.
    V. K. Ahluwalia, M. Chopra, and R. Chandra, J. Chem. Res. (S), 162 (2000).Google Scholar
  7. 7.
    L. V. G. Nargund, V. V. Badiger, and S. M. Yarnal, Eur. J. Med. Chem., 29, 245 (1994).CrossRefGoogle Scholar
  8. 8.
    M. van Laar, E. B. Volkerts, and M. Verbaten, Psychopharmacology, 154, 189 (2001).CrossRefGoogle Scholar
  9. 9.
    K. Danel, E. B. Pedersen, and C. Nielsen, J. Med. Chem., 41, 191 (1998).CrossRefGoogle Scholar
  10. 10.
    Y. A. Issac and A. A. Aly, Z. Naturforsch., 58b, 1227 (2003).Google Scholar
  11. 11.
    A. A. Aly and S. A. Nassar, Heteroatom Chem., 15, 2 (2004).CrossRefGoogle Scholar
  12. 12.
    A. A. Aly, Phosphorus, Sulfur, Silicon, Relat. Elem., 178, 2415 (2003).CrossRefGoogle Scholar
  13. 13.
    A. A. Aly, J. Chin. Chem. Soc. (Taipei), 51, 1381 (2004).Google Scholar
  14. 14.
    A. A. Aly, Ph.D. Thesis, Zagazig University, 2008.Google Scholar
  15. 15.
    H. Vieweg, S. Leistner, and G. Wagner, Pharmazie, 43, 358 (1988).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • A. M. Amer
    • 1
    Email author
  • A. F. El-Farargy
    • 1
  • N. M. Yousif
    • 2
  • A. A. Fayed
    • 2
  1. 1.Chemistry Department, Faculty of ScienceZagazig UniversityZagazigEgypt
  2. 2.National Research Center, Photochemistry DepartmentCairoEgypt

Personalised recommendations