Derivatives of three new classes of heterocyclic compounds have been synthesized. The first class comprises the synthesis of pyrimidino- and imidazolopyrazolopyridazine using 11 H-dibenzo[f,h]pyrazolo[3,4-c]-cinnoline-13-amine. The second class involves the synthesis of triazine derivatives using 11 H-dibenzo-[f,h]pyrazolo[3,4-c]cinnoline-13-diazonium chloride. The third class deals with the synthesis of polycyclic compounds using dibenzo[f,h]pyridazino[4,5-b]quinoxaline-10,13-diamine. The pharmacological screening has shown that several of these compounds have good antiparkinsonian activities comparable to Benzatropine. The detailed synthesis, spectroscopic data, and pharmacological properties are reported.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 129–135, January, 2011.
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Amer, A.M., El-Farargy, A.F., Yousif, N.M. et al. Synthesis and pharmacological activities of some dibenzopyrazolocinnolines and dibenzopyridazinoquinoxalines. Chem Heterocycl Comp 47, 101–107 (2011). https://doi.org/10.1007/s10593-011-0726-z
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DOI: https://doi.org/10.1007/s10593-011-0726-z