Novel nucleophilic rearrangement of 1-substituted isoquinolines using an alcoholic sodium hydroxide solution

  • V. I. TereninEmail author
  • A. A. Volkov
  • A. S. Ivanov
  • E. V. Kabanova

The reactions of 1-substituted isoquinolinium salts have been studied in the cases of the 1-isopropyl-2-methyl- and 2-methyl-1-cyclohexylisoquinolinium iodides using an alcoholic solution of sodium hydroxide. The possibility of preparing a wide range of spirocyclic ketones, alcohols, amino alcohols, and isochroman-3-ones has been demonstrated.


isoquinoline isochroman-3-one sodium ethylate reduction nucleophilic rearrangement 


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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. I. Terenin
    • 1
    Email author
  • A. A. Volkov
    • 1
  • A. S. Ivanov
    • 1
  • E. V. Kabanova
    • 1
  1. 1.M. V. Lomonosov State UniversityMoscowRussia

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