Chemistry of Heterocyclic Compounds

, Volume 47, Issue 1, pp 60–66 | Cite as

Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones

  • V. Kanagarajan
  • J. Thanusu
  • M. R. Ezhilarasi
  • M. GopalakrishnanEmail author

A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains.


m-chloro-perbenzoic acid spiropiperidinyl-1,2,4-triazolidine-3-thiones antibacterial activity antifungal activity one-pot synthesis 


The authors are thankful to the NMR Research Centre, Indian Institute of Science, Bangalore for recording spectra. One of the authors (V. Kanagarajan) is grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, Republic of India for providing financial support in the form of a CSIR-Senior Research Fellowship in Organic Chemistry. Another author (J. Thanusu) is highly thankful to Annamalai University authorities for providing financial support in the form of a Research Fellowship.


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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. Kanagarajan
    • 1
  • J. Thanusu
    • 1
  • M. R. Ezhilarasi
    • 1
  • M. Gopalakrishnan
    • 1
    Email author
  1. 1.Synthetic Organic Chemistry Laboratory, Department of ChemistryAnnamalai UniversityTamil NaduIndia

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