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Synthesis and antibacterial activity of some novel pyrazolopyridine derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Eight pyrazolo[3,4-b]pyridine derivatives have been synthesized by Friedländer condensation of 5-aminopyrazole-4-carbaldehyde with active methylene compounds in basic medium. These compounds have been screened for their antibacterial activity against two Gram-negative and two Gram-positive bacterium. Pyrazolopyridines having the carboxamide group at the 5-position showed moderate to good activity against P. aeruginosa, E. coli, S. pneumoniae, and B. cereus.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology, Rourkela, 769008, India

    N. Panda, S. Karmakar & A. K. Jena

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  1. N. Panda
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  2. S. Karmakar
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  3. A. K. Jena
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Correspondence to N. Panda.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1857–1866, December, 2010.

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Panda, N., Karmakar, S. & Jena, A.K. Synthesis and antibacterial activity of some novel pyrazolopyridine derivatives. Chem Heterocycl Comp 46, 1500–1508 (2011). https://doi.org/10.1007/s10593-011-0699-y

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