Modified methods are proposed for the preparation of the ethyl ester and alkylamides of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. A comparative analysis has been carried out of the steric structure and diuretic activity of the synthesized compounds and the previously studied, and closely structurally related, 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo-[3,2,1-ij]quinoline-2-carboxamides.
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*For Communication 193, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1806–1815, December, 2010.
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Ukrainets, I.V., Golik, N.Y., Andreeva, K.V. et al. 4-Hydroxy-2-quinolones. 194*. 1-Hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid alkylamides. Synthesis, structure, and biological properties. Chem Heterocycl Comp 46, 1459–1466 (2011). https://doi.org/10.1007/s10593-011-0692-5
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DOI: https://doi.org/10.1007/s10593-011-0692-5