Chemistry of Heterocyclic Compounds

, Volume 46, Issue 11, pp 1364–1370 | Cite as

4-hydroxy-2-quinolones. 191.* synthesis, tautomerism and biological activity of benzimidazol-2-ylamides of 1-r-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids

  • I. V. Ukrainets
  • L. A. Grinevich
  • A. A. Tkach
  • O. V. Gorokhova
  • V. N. Kravchenko
  • G. Sim

A series of benzimidazol-2-ylamides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids was prepared in a search for biologically active compounds. These compounds exist in the crystal exclusively in the amide form, while in solution amide↔imide tautomerism is observed. The results of a study of the antithyroid and antituberculosis activities of these compounds are given.


2-aminobenzimidazole 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides antithyroid activity antituberculosis activity tautomerism 


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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • L. A. Grinevich
    • 1
  • A. A. Tkach
    • 1
  • O. V. Gorokhova
    • 1
  • V. N. Kravchenko
    • 1
  • G. Sim
    • 2
  1. 1.National Pharmaceutical UniversityKharkivUkraine
  2. 2.Far East State Medical UniversityKhabarovskRussia

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